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Seborrheic Keratosis (SK) is one of the most benign epidermal neoplasms that rarely transform malignant. In this case, we report a SK malignant transformation to Bowen Disease (BD) with no relation to sun expose in China. The patient is a 72-year-old woman with a black skin lesion on her back. Clinical diagnosis of SK was made then a completely excision was performed. Histologically result showed a part of atypia keratinocytes with full-thickness in epidermis but no invasion to dermis arising in typical SK area. Thus, a pathologic diagnosis of BD arising in SK was made. This indicate that malignant transformation in SK can occur in the absence of sun expose.
