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In order to offer reference points on the current stage of development of clinical psychological nursing and future research hotspots, an analysis of clinical psychological nursing research hotspots in China and variation patterns was conducted. Wanfang provided clinical psychology nursing study literature. The research sample was drawn from data from the years 2007-2009, 2010-2012, and 2013-2015. To do keyword word frequency analysis and construct a keyword co-occurrence matrix, a bibliographic co-occurrence analysis system (BICOMB software) was employed. Additionally, the Net sketch tool from Uci net software was utilized to produce visible network diagrams. A total of 27890 articles were found, and word frequency analysis revealed that anxiety, depression, the elderly, expecting women, coronary heart disease, diabetes, breast cancer, perioperative period, quality of life, and psychological intervention were the most frequently used keywords. Anxiety, depression, health education, and the perioperative phase were found to be constant hotspots in research; expectant women became a hotspot in 2010-2012, and quality of life and efficacy became hotspots in 2013-2015. Clinical psychological nursing research hotspots in China have progressively included the effectiveness of psychological nursing and its effects on patient quality of life, in addition to the care process. In addition, the occurrences of ailments and people’s health consciousness have changed research hotspots.