A randomised trial on the effects of co-administering propofol with clonidine and ketamine duringcolon cancer surgery

With the addition of clonidine and ketamine to TIVA propofol, analgesic effects can be further enhanced, resulting in an even more potent anaesthetic without endangering patient safety. The goal of this study is to ascertain if a propofol infusion in combination with  clonidine and ketamine is more effective at reducing IL-8 levels, maintaining surgical stability, and reducing postoperative pain and morphine use.