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Hyperostosis frontalis interna (HFI) is a condition that involves thickening of the frontal region of the endocranial surface with midline sparing. It is observed in radiographic images of the cranium in living subjects and upon dissection in deceased subjects. There is little information related to the impact that hyperostosis frontalis interna has on living patients. In this case of severe hyperostosis frontalis interna, the subject was a 77-year-old female human donor who had an overwhelming number of co-morbidities. The purpose of this case study is to report an unusual case of hyperostosis frontalis interna.