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Medical Toxicology: Current Research

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Anaphylaxis to proton pump inhibitor: Pantoprazole -induced Kounis syndrome

Author(s): Himmatrao Saluba Bawaskar*, Parag Himmatrao Bawaskar and Pramodini himatrao Bawaskar

Kounis syndrome is characterized by hypersensitivity and coronary artery disorder due to various environmental exposures, drugs and proton pump inhibitors (PPIs). Vasospastic allergic angina, allergic myocardial infarction and stent thrombosis with occulting thrombus infiltrated by eosinophils and histamine liberated by recruited mast cells are all seen in Kounis syndrome.


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