Journal of Sexual & Reproductive Medicine

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Andropause and depression: A perspective for the clinician

Author(s): Brian Bexton*

Major depression and androgen deficiency are both frequent in men older than age 40 years, and the prevalence of both tends to increase with age. In evaluating major depression, clinicians should be aware of this relationship and request laboratory analysis of total and bioavailable testosterone, when indicated. Testosterone replacement therapy can be beneficial in relieving the symptoms of andropause and in increasing a patient’s response to antidepressant treatment.

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