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An endophytic fungus, Chaetomium fusiforme, was isolated from a liverwort known as Scapania verrucosa. A comparative analysis of the chemical constituents present in the ether extracts from both S. verrucosa and the culture of C. fusiforme were conducted using Gas Chromatography-Mass Spectrometry (GC/MS). The yield of ether extract, based on dried plant material, was determined to be 0.6%, and a total of 59 compounds were identified in S. verrucosa. Among the characterized compounds in S. verrucosa, (+)- Aromadendrene (9.12%), hexadecanoic acid (6.92%), 6-isopropenyl4,8a-dimethyl-1,2,3,5,6,7,8,8a-octahydro-naphthalen-2-ol (5.97%), stetrachloroethane (5.61%), and acetic acid (5.30%) were found to be the most abundant components. These compounds collectively accounted for 84.64% of the total extract in S. verrucosa. In contrast, the constituents of the cultured endophyte extract were primarily composed of acetic acid (35.05%), valeric acid, 3-methyl-, methyl ester (21.25%), and butane-2,3-diol (12.24%). Although the chemical composition of the extracts from S. verrucosa and its endophyte displayed little correlation, both extracts exhibited antifungal and antitumor activities. Moreover, C. fusiforme demonstrated a broader spectrum of activities. on biomaterial technology because these materials effectively support cell culture or cell transplantation with high cell viability or activity.