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OBJECTIVE: To observe the clinical effect of LiuWei DiHuang bolus combined with acarbose to treat early diabetic nephropathy. Method: A total of 117 diabetic outpatients who met the study inclusion criteria were randomly assigned to an observation group and a control group. The control group was treated with glucoba, while the observation group was treated with LiuWei DiHuang bolus combined with acarbose. Result S: The observation group exhibited an impressive cure rate (91.5%), which was better than the total effective rate (P<0.05). Conclusion: Administration of LiuWei DiHuang bolus combined with acarbose appeared to be highly effective in treating early diabetic nephropathy, and may be a clinically valuable treatment alternative.