All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Clinical Pharmacology and Toxicology Research

Sign up for email alert when new content gets added: Sign up

Comparable CNS mechanisms for locomotor rhythm generation and selfconsciousness expression

Author(s): Pierre A. Guertin*

Locomotor rhythm generation depends upon transmembrane voltage oscillations, NMDA ionophores and 5-HT receptors in the spinal cord. A clear demonstration of such a command center for locomotion in the lumbosacral area of the spinal cord has generally been attributed to Sten Grillner. He elegantly showed that spinal cord-transected (Tx) cats, after decerebration, can still express locomotor-like activity monitored from hindlimb nerves [1]. Although its functional organization remains incompletely understood, one of the first models has described the spinal locomotor CPG as two half-centers (flexor and extensor) reciprocally inhibiting each other rhythmically. The mutual inhibitory interactions, ensured by inhibitory neurons, would enable only one half-center to be active at a given time. The activity of the active half-center would gradually reduce due to some fatigue, allowing an activation of the antagonistic half-center which, in turn, would then inhibit the active halfcenter, hence switching the locomotor phase from flexion to extension and vice versa [1]. Those half-centers were found to depend upon neuromodulation and neurotransmitters for normal activity.

Full-Text | PDF

Recommended Conferences

4th International Conference on Toxicology and Clinical Toxicology

Dubai, United Arab Emirates