44 2033180199
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Journal of Experimental and Clinical Microbiology

Sign up for email alert when new content gets added: Sign up

Development of a skin- and neuro-attenuated live vaccine for varicella

Author(s): Hua Zhu

Varicella caused by the primary infection of a ubiquitous neurotropic human alpha-herpesvirus, varicella-zoster virus (VZV), exerts a considerable disease burden worldwide. The current live Varicella Vaccine Strain (vOka) is generally safe and effective. However, vOka retains full ability to cause mild varicella, establish latency and reactivate to cause herpes zoster that is often clinically indistinguishable from wild-type disease in vaccine recipients. These adverse effects could be the result from vOka haplotypes carrying the disease-causing alleles, raising safety concerns. Therefore, there is a need for next-generation varicella vaccines with reduced pathogenic risk to improve the current strategy for establishing worldwide herd immunity against this disease. 


PDF
 
Google Scholar citation report
Citations : 46

Journal of Experimental and Clinical Microbiology received 46 citations as per Google Scholar report

pulsus-health-tech
Top