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Neurodevelopmental Disorders and Treatment

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Author(s): Katty Jones

Dopamine (DA) interacts with the human dopamine transporter (hDAT) and dopamine receptors in the central nervous system (CNS) to govern a variety of psychological and behavioural functions. The targeted binding of medicines to hDAT affects the roles of DA in CNS function; hence, hDAT plays a vital role in neurophysiology and neuropathophysiology. To examine the DAhDAT interaction and the effects of a range of medicines that are dependent on it, such as psychostimulants and antidepressants, an effective experimental method is required. Dopamine (DA) is a catecholamine neurotransmitter that regulates a variety of psychological and behavioural functions in Mammalia's central nervous system (CNS) via biochemical interactions with the dopaminetransporter (DAT) and dopamine receptors (DARs). Tyrosine (Tyr) is converted to L-DOPA and then to DA by dopaminergic neurons in the ventral tegmental region, substantia nigra pars compacta, and the arcuate nucleus of the hypothalamus. The DA neurotransmitter functions in a series of stages.

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