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Clinical Pharmacology and Toxicology Research

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Effect of oral administration of silver nanoparticles on blood parameters and bone marrow cells of female albino rats

Author(s): Mahmoud M Elalfy*, Eman E Abdraheem and Mamdouh Abouelmagd

Background: The aim of this study was to investigate the effect of oral acute dosing with silver nanoparticles (AgNPs) and identify potential genotoxicity and their effect on blood parameters in the female albino rat.

Methods: Eighteen female rats were used to assess the acute effects of AgNPs. Rats in the treatment group were gavaged with 1 mL of di-ionized water containing AgNPs at dose of 1/50 and 1/100 of LD50 weight on 6th to 15th day of gestation of pregnant female albino rats. Control rats received 1 mL of di-ionized water only. After 20 days of gestation, rats were euthanized, blood samples and bone marrow were collected to investigate for hematologic and genotoxicity of sliver nanoparticles.

Results and conclusion: AgNPs were enhanced hematotoxiciy in female albino rats at time of delivery and after end of treatment evidenced by reduced level of RBC, WBC, hemoglobin and calculated hemo-indices. Notably, AgNPs enhanced genotoxicity by increased chromosomal aberrations at dose dependent manner. While no change in micronuclei numbers when compared to control group. Taken collectively, AgNPs considered not safe as pharmacological agent during pregnancy.

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