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40 patients diagnosed with GBS recruited from neuropsychiatry department of Nasser Institute Hospital. They were assessed clinically using the Hughes scale at onset and 3-6 months later. In follow up patients were divided into GBS with good and those with poor prognosis according to their score, Good prognostic group has only 2 or less in the Hughes score while above two patients were considered having poor prognosis At presentation, some lab studies were done to them including CSF examination. Nerve conduction study was done to all the 40 patients. They were treated with plasma pharesis sessions with different number of sessions (6 or less versus more than 6). Reassessment of patients using Hughes GBS disability scale, and nerve conduction study; done 3-6 months after onset.