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Combined hepatocellular cholangiocarcinoma [HCC-CC] is a rare form of primary liver cancer, showing a mixture of hepatocellular and biliary features. Data suggest that most CHC arise from hepatic progenitor cells [HPCs]. Recent classification of combined HCC-CC is usually based on three categories separate type, transitional type and intermediate type. The case reported below, concerns the incident of a liver tissue measuring 11 × 8.5 × 4 cm. and weighing 155 gr. with an adjacent fatty area of 12 × 6 × 3 cm and an adherent gall bladder, 8.5 cm in length and 5 cm in diameter. We investigated the type of HCC-CC and immunophenotypes using different hepatic progenitor cell markers and classic histological staining technique.