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Abdominal Tuberculosis (TB) is well known clinical entity and it involves peritoneum, lymph nodes, intestine and solid organs. Involvement of hepatobiliary tract and pancreas is less common. It often mimics as malignancy and often possess diagnostic dilemma Here, we are presenting data and our experience of Six cases diagnosed and managed as heptopancreaticobiliary (HPB) tuberculosis Two patients initially suspected to have malignancy on the basis of clinical and radiological findings. One patient found to have numerous small lesions involving both lobe of liver, during laparoscopic cholecystectomy, giving a visual impression of possibly metastatic in nature which turned out to be of tubercular on histopathological examination. On further evaluation he was diagnosed to have disseminated TB. Three patients presented with fever and managed as case of pyogenic liver abscess. There was no response to broad spectrum IV antibiotics. On further evaluation tubercular nature of liver abscesses confirmed and all 03 patients successfully treated with ATT. High index of suspicion and keeping HPB TB is one of differential diagnosis is of paramount importance for positive outcome.