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Clinical Pharmacology and Toxicology Research

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Hepatorenal effects of chlorfenapyr as pro-insecticide in female Sprague Dawleyrats in postnatal model of toxicity and in HepG2 cell line.

Author(s): Mahmoud M. Elalfy1 , Mohamed S. Abomosallam1 , Fathy R. Sleem1 , Emad A. Abassand Mona G. Elhadidy2

Chlorfenapyr is good candidate insecticide for control of vectors blood borne diseases like malaria. As little information about Chlorfenapyr toxicity and possibility of its residue’s presence in food stuffs, milk and environment, we explore the postnatal toxic effects of Chlorfenapyr in female Sprague dawley rats and its pups. Chlorfenapyr was given orally at doses of 0,54 and 108 mg/kg to female albino rats immediately at first day after delivery till 21 days of lactation. All dams and its pups were weighted, euthanized and blood was separated for serum separation and tissues were preserved either at 4c as tissue homogenate for measurements of oxidant/ antioxidants levels or in buffered formalin for histopathological examination. The highest dose of Chlorfenapyr induced hepatorenal toxicity in dams and its pups with evidence of increase liver enzymes and creatinine level when compared to control groups


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Citations : 2

Clinical Pharmacology and Toxicology Research received 2 citations as per google scholar report

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