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Human anatomy has traditionally been taught using a “standard” model; however, significant variability exists across individuals. This article explores the sources, extent, and significance of anatomical variations in humans. These variations can stem from genetic, environmental, developmental, and evolutionary factors. Recognizing these differences is essential in clinical practice, education, surgical planning, and personalized medicine. This review synthesizes recent findings on anatomical variability and outlines its implications for healthcare professionals and anatomists.