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In experimental research was investigate morphological changers in organs of central nervous system (CNS) – spinal cord, cerebrum and cerebellum and in organs of immune system– thymus and spleen after initiation of experimental allergic encephalomyelitis (EAE) in rats. Process of remyelination was induce after injections of Rebif® (interferon beta-1a) and laser therapy in condition of experimental model (EAE). Was observe changers of demyelination and remyelination in nerve fibers and reactions in neurons of central nervous system (CNS) on 21 days and 39 days after initiation of EAE. Also, was study reactions in thymus and in spleen on 21 days and 39 days after initiation of EAE. Histological sections of thymus and spleen was stain hematoxylin – eosin and azure II-eosin. Histological sections of the spinal cord, cerebrum and cerebellum was stain by cresyl violet and toluidine blue (by Nissl). By methods of electron microscopy and morphometry was investigate demyelination and remyelination in nervous fibers. After initiation of EAE reactive changers in thymus was include – formation of small nodules in cortical part of lobules, decrease amount of lymphocytes in cortex of lobules in early period on 21 days. In late period – 39 days after initiation EAE and influence of Rebif® (interferon beta-1a) and laser therapy by 2 weeks was observe similar changers - increase amount of lymphocytes in cortex. Reactive changers in spleen after remyelination was include increase amount of lymphoblasts and white pulp in parenchyma. After influence of Rebif® (interferon beta-1a) by 2 weeks, we observed process of remyelination. We observed the percentage of neurons with unmodified, moderate and severe structural changes, changers of myelinated and unmyelinated nervous fibers.
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