44 2033180199
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Nanotechnology Letters

Sign up for email alert when new content gets added: Sign up

Impact of pre-existing immunity to influenza on Live-attenuated influenza vaccine

Author(s): Tanay Shukla*

Between 2010 and 2016, the Live Attenuated Influenza vaccine (LAIV) demonstrated varied effectiveness against influenza in the United States, leading to a recommendation against its use. In stark contrast, pre-clinical investigations have repeatedly proven that LAIV outperforms inactivated influenza vaccinations against mismatched Influenza Viruses (IIV). This difference in reported vaccination efficacies between pre-clinical and clinical research may be explained in part by the limitations of influenza animal models. The absence of pre-existing immunity in animal models, in particular, has lately emerged as a potential reason for inconsistencies between preclinical and human investigations. The purpose of this article is to discuss the possible influence of pre-existing immunity on LAIV-induced immunogenicity, with a focus on cross-protective immunity.

Full-Text | PDF
Google Scholar citation report
Citations :

Nanotechnology Letters received citations as per Google Scholar report

Nanotechnology Letters peer review process verified at publons