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Candidiasis is a contamination brought about by a yeast molded organism which incorporates Candida sexual orientation. Candida albicans is a sharp microorganism, which causes over 80% of vaginal contaminations. The point of this examination was to decide the impact of ozonized theobroma oil vaginal ovules in the treatment of incited vaginal candidiasis contrasted with Ketoconazole ovules in Sprague Dawley female rodents. Methods and Findings: Animals were ovariectomized and infused with a hormonal treatment following 14 days so as to realize the oestrus cycle. Following 48 hours rodents with keratinous cellules were vaginally contaminated with an inoculum of 106-107 Candida albicans in 0.1 mL of phosphate cushion arrangement. Five creatures bunches were contemplated: bunch I (without treatment), bunch II (rewarded with unozonized theobroma oil ovules), bunch III (rewarded with ketoconazole ovules), bunch IV (rewarded with 10% ozonized theobroma oil ovules), and gathering V (rewarded with 20% ozonized theobroma oil ovules). Exudates were made before starting the treatment, 5 and 10 days during the treatment and 48 hours after the finish of treatment. Results exhibited a reduction of 0.7 log of the quantity of rodents with contamination following 5 days of treatment with 20% ozonized theobroma oil ovules; be that as it may, it was not watched disease in rodents following 10 days. A comparable outcome was gotten with ketoconazole ovules.