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Clinical guidelines for health care practitioners are being developed at an increasing rate these days. However, this does not necessarily imply that these guidelines are followed. The goal of this meta-review is twofold: first, to obtain a better knowledge of which elements influence guidelines implementation, and second, to provide insight into the "state-of-the-art" in this field of research. Our criteria for inclusion were met by 12 systematic reviews. There were no previous systematic meta-reviews that fulfilled all of our inclusion criteria. Only "small" or "minimum" problems were found in two of the twelve inspections, according to the criteria. The remaining eight reviews were rated in the low to mid-range, indicating "severe" or "serious" problems. A significant number of reviews (though not all) show that effective techniques often include numerous components, and that using a single tactic, such as reminders or an educational intervention, is ineffective. Furthermore, the qualities of the guidelines themselves have an impact on their practical use. Guidelines that are simple to grasp, try out, and do not require specialized resources, for example, have a better probability of being implemented. In addition, professional features. Existing studies have identified a number of elements that determine whether or not guidelines are followed. However, there is still a lack of evidence, and further research is needed, such as comparing combinations of implementation strategies vs single strategies.