Models of blast TBI, and the implications for seizure risk

TBI caused by explosive blast exposure is a primary cause of battle casualties. It is also suspected of being a major factor to war-related mental health disorders. A clinically significant outcome of all forms of TBI is an increased likelihood of developing seizures and epilepsy. Seizures have been observed in patients with bomb injuries during the Global War on Terror, although the actual occurrence is unknown. Seizures reinforce the theory that an explosive blast causes both cellular and structural brain damage. Unfortunately, the precise mechanism by which explosions induce brain damage remains unknown, complicating the development of effective medicines and mitigation techniques. A thorough neuropathological examination is required to aid comprehension. Histopathological procedures are incredibly helpful and necessary for this. Following that, we will go over the pathology findings from recent preclinical explosive explosion investigations, including those using immunohistochemistry and special staining methods.