Movement disorder spectrum in chronic kidney disease(ckd) with clinical and radiological differentiation between patients with parkinsonism in ckd and idiopathic parkinsons disease(ipd)

Chronic kidney disease (CKD) is defined as kidney dysfunction with progressive decline in glomerular filtration rate 60% patients with CKD has neurological symptoms in different stages of disease. Movement disorders are often dominating neurological symptoms. Among them myoclonus, restless leg syndrome, parkinsonism, asterixis are common presentation. In our study, we have analyzed the movement disorderspectrum in 71CKD patients and 50 patients with idiopathic parkinsons disease (IPD). Parkinsonism and myoclonus were the most common movement disorder being present in 46.5% and 45% of the cases. Postural tremor (13%) and restless leg syndrome (10%) were present in minority of patients. Bradykinesia (100%), rigidity (82%), postural instability (79%) and rest tremor (18%) were also present in the subset of patient having parkinsonism. Pyramidal sign and gait disorder were frequent in CKD patient with parkinsonism and rest tremor is less common. Hypertension and diabetes mellitus are more common seen in parkinsonism patients with CKD than those without.