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ART drug is widely used Anti-HIV agents. Of these, molecular recognition in their molecular nucleus likes diarylpyrimidine, benzoxazinone, heterocyclic most present in ART. Apart from these, some hetero atom along with some special core group have been reported. They are effective and not very costly, though there are also possibilities of ART adverse reactions common with use of ART. Cross reactivity between for example Etravirine and Rilpivirine, earlier reported may exceed 30%. Common adverse drug reaction for highly protein bound ART, includes hypersensitivity reactions were characterized by rash, fever and sometimes organ involvement including, but not limited to, severe rash or rash accompanied by fever, general malaise, fatigue, muscle or joint aches, blisters, oral lesions, conjunctivitis, hepatitis and eosinophilia. indices were included. Adverse drug reactions caused by drugs belonging to no longer their therapeutic effect or alter their adverse events profile. Hence, this study has undertaken to promote health care setting, so researcher movement initially began inside hospitals and clinics. This study adverse drug reaction has setting drug discovery in HIV technology in collaboration with microbiologist, physicians, pharmacist, nurse practitioners and other healthcare professionals then there is adverse reactions could have been prevented or may lead to zero adverse reaction ART. Also, this study has shown of critical analyzing the clinical profile of these reactions, grading them and trying to figure out ways to deliver actual drug discovery to prevent these adverse reactions. Reports were messaged to see clinical pharmacist stating explicitly that the clinical pharmacist cares for patients in all health care settings emphasizes two points: that clinical pharmacist provides care to their patients and that this practice can occur in any practice setting. The study aims to assess the role of clinical pharmacist in identification and reporting of adverse drug reactions in antiretroviral therapy and consideration of new pattern clinical study.