In optic pathway-related neuro-ophthalmologic diseases, the morphological characteristics of mGCC thickness demonstrated characteristic changes that are similar to that of visual field, and mGCC analysis had value of objective positioning analysis. In this retrospective case study, a total of 32 patients with optic pathway-related neuro-ophthalmology diseases were enrolled. A Swept-Source Optical Coherence Tomography (SS-OCT) was used to scan and analyze the morphological characteristics of the mGCC thickness and the Peripapillary Retinal Nerve Fiber Layer (pRNFL) thickness in these patients, which were compared with the visual field changes at the corresponding phase to analyze their relationship.