Stroke neurorehabilitation: Targeting CNS neural mechanisms of gait

Human gait is intricately controlled by the central nervous system (CNS), which also includes neural connections between the brain and spinal cord, interhemispheric communication, affective ascending neural pathways, descending cortical regulation, and whole brain networks of functional connectivity. The administration of gait training utilising externally targeted techniques, such as the treadmill, weight support, over-ground gait coordination training, functional electrical stimulation, bracing, and walking assistance, was the subject of numerous significant studies in the past. Neurorehabilitation gait training has yet to be accurately focused and measured in accordance with the CNS source of gait control, despite the fact that the phenomena of CNS activity-dependent plasticity has served as the foundation for more recently developed gait training techniques.