The changing role of diagnostic genomics in kidney transplantation

Chronic Kidney Disease (CKD), which affects both juvenile and adult patient populations, is largely caused by monogenic forms of heritable kidney disease, with up to 11% of patients under the age of 40 developing end-stage Kidney Failure (KF) and needing a kidney transplant. The subject of diagnostic genomics in nephrology is constantly developing, and it now plays a crucial part in the evaluation and management of kidney transplant recipients and the linked donor pairs. Genomic testing can aid in the diagnosis of KF in kidney transplant patients and help predict the prognosis for graft survival and the likelihood of primary kidney disease recurrence. At-risk relatives who are donors can be tested for a gene mutation that has been found in the recipient and rejected if it is present.