The hypophyseal microvasculature portal system located at the base of the brain connects the hypothalamus arcuate nucleus and anterior pituitary gland for rapid and undiluted transport of the neurohormones vital for infertility prevention.

The Enteric Nervous System (ENS) includes the gut microbiota diversification interacting with the epithelial and immune cells of intestinal stomach, small and large intestine, and colon. The ENS controls motility, fluid acid / base homeostasis, and blood flow inside the gastrointestinal tract postnatally for ENS maturation. The vagus nerve is the modulator of the parasympathetic nervous system that uses a bidirectional communication system with the prevertebral ganglia. Nutrients including vitamins, minerals, neurotransmitters, peptides, and hormones travel through ENS via the vagus nerve in the blood up the spine crossing the blood brain barrier to connect sensory, mood, appetite, sleep and cognitive regulation and function. Nervous system essential vitamins are B group (1, 3, 5, 6, 9, 12), C, zinc, magnesium L threonate, vitamin D, omega three fatty acids, L -theanine amino acid, l-methyl folate, S-Adenosylmethionine (SAM-e), and 5 HTP serotonin and dopamine.