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Journal of Clinical Microbiology and Infectious Diseases

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The influence of BMI on adaptive immune cells in human bone marrow

Author(s): Paul Arya*

Obesity has been linked to oxidative stress and chronic inflammation. In the aetiology of age-related disorders like immunosenescence, both states are crucial. By secreting chemicals that affect the phenotypic of immune cells, adipose tissue can modify how the immune system responds to foreign invaders. It has been demonstrated in mice that the Bone Marrow (BM) is crucial for the upkeep of adaptive immune cells that have encountered antigens. Recently, various research teams have looked into how long effector/memory T cells can survive in the human BM. Despite this, it is unknown if having a high Body Mass Index (BMI) will have an impact on the generation of chemicals that support the maintenance of immune cells in the BM. In matched BM and PB samples taken from people with various BMIs, the frequency and phenotype of immune cell groups were assessed by flow cytometry. The expression of BM cytokines was also evaluated. Additionally, the effect of Cytomegalovirus (CMV) on T cell subsets was taken into account by separating the donors into CMV- and CMV+ groups. According to our research, a higher BMI may have an impact on the phenotypic and maintenance of adaptive immune cells in the BM. While levels of IL-15 and IL-6, which support the survival of highly differentiated T cells, and oxygen radicals rose in the blood of overweight individuals, CD8+ T cell production of IFN and TNF decreased.

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