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Asymmetric left face edema due to left subclavian vein thrombosis and its management is presented in this case report. 30 years‐old woman with left arm and face edema had thrombosis from the middle part of left subcavian untill superor vena cava and brachiocephalic vein. Low molecular weight heparin and oral anticoagulant therapy were shown to provide clinical improvement, although it did not provide improvement in the anatomy. The literature is reviewed.