Utilizing natural compounds in glioma immunotherapy

The increasing focus on glioma immunotherapy stems from the recognition of the crucial role played by the immune system in inhibiting tumor growth. Clinical trials are already underway to assess various immunotherapy approaches, such As Immune Checkpoint Inhibitors (ICIs), vaccines, chimeric antigen receptor T-cell (CAR-T cell) therapy, and virus-based treatments. However, the practical application of these immunotherapies is hampered by their significant side effects and limited effectiveness due to factors like glioma heterogeneity, antigen evasion, and the presence of a Glioma Immunosuppressive Microenvironment (GIME). In light of these challenges, natural products have emerged as a promising and safe strategy for treating glioma. Many of these natural compounds exhibit potent anti-tumor properties and the ability to regulate the immune system, thereby counteracting the effects of the GIME. This review provides an overview of the current status of immunotherapy strategies for glioma, including the obstacles they face. Additionally, it delves into recent developments in the use of natural products for glioma immunotherapy