Department of Biotechnology and Biochemistry, Oriental Institute of Science and Technology, West Bengal,Vidyasagar UniversityMidnapore-721102, India

Publications

• Research Article   
  The popular 3675SGF deletion in nsp6 domain of ORF1ab polyprotein of SARS-CoV-2 was spread into Alpha, Beta, Gamma, Iota and Omicron variants except highly infectious and death promoting Delta variant
  Author(s): Asit Kumar Chakraborty*
  
  The SARS-CoV-2 was appeared in mid-2020 but the first RNA sequence was available since December, 2020. The higher transmission and disease severity were seen since acquisition of D614G dominant point mutation in spike protein as well as P4715L point mutation in the RNA-dependent RNA polymerase (RdRp). The next event occurred in B.1.1.7 Alpha variant was acquisition of N501Y point mutation and 69HV two AAs deletion in the spike protein. Interestingly, 3675SGF three AAs deletions were also occurred in ORF1ab polyprotein in B.1.1.7 variants. The appearance of notorious Delta variant in Mid-2021 was shocking as too many deaths happened worldwide. The Delta variants (B.1.617.2 and AY.X) acquired 157FR two AAs deletion instead 69HV in B.1.1.7 variant. Here, we showed that Delta variant was spread worldwide but has no 3675SGF deletion. Moreover, 3675SGF deletion was found in all Omicron vari.. Read More»
  DOI: 10.37532/puljmbr.2023.6(2).41-44

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