Editorial Office, Journal of Kidney Treatment and Diagnosis, Windsor, Berkshire, England

Publications

• Commentary   
  Adaptive nephrology
  Author(s): Hanna Koch* and Paul Hohenlohe
  
  Evolutionary medicine, a new field that broadens study boundaries, has evolved in the last 20 years. Progressive kidney disease follows nephron loss, hyperfiltration, and inadequate healing, a process known as "maladaptive." Evolutionary adaptation, in contrast to physiological (homeostatic) adaptation, is the result of reproductive success, which represents natural selection. Environmental mismatch or evolutionary trade-offs can lead to evolutionary reasons for physiologically maladaptive responses. A fragile, energy-hungry renal tubule and a hypoxic, hyperosmolar microenvironment were produced as a result of evolutionary adaption to a terrestrial environment. Natural selection promotes a successful energy investment strategy: through the reproductive years, energy is committed to maintaining nephron integrity, but after age 40, this decreases due to senescence... Read More»
  DOI: 10.37532/puljktd.22.5(6).1-4

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