Commentary
Stress as a potential regulator of pharmacotherapy outcomes
Author(s): Nia Sharma*
Accumulating clinical evidence suggests that there are significant inter-individual differences in the efficacy of standard treatment protocols used for a variety of diseases, including diabetes, hypertension, depression, cancer, and epilepsy, as well as differences in drug-related side effects and toxicity. When multidrug therapy regimens are used, the issue frequently becomes more apparent. The causes for this variation appear to be connected to the multi-factorial regulation of the machinery governing drug destiny and biological activity in the body. This machinery includes cell-signaling, metabolic, and transport systems, which are encoded by their respective genes and, in turn, are controlled by a variety of parameters such as age, gender, race, lipidemic, and endocrinological status. The respiratory, immunological,cardiovascular,gastrointestinal,endocrinological, and central neu.. Read More»
DOI:
10.37532/pulnp.2022.2(2).16-18
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