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Department of Physiology and Pathophysiology, Institute of Cardiovascular Sciences, St. Boniface Research Centre,Max Rady College of Medicine, Winnipeg, Manitoba, Canada


  • Reviews   
    The role of the sympathetic nervous system in sudden cardiac death
    Author(s): Ajaipal S Randhawa, Ravideep S Dhadial, Adriana Adameova, Eman Ashgar and Naranjan S Dhalla*

    Sudden cardiac death (SCD) is a complex disease and represents one of the largest burdens to health care worldwide. It is known to be associated with various disease conditions, including but not limited to, cardiac arrhythmias, coronary artery disease, cardiomyopathies, valvular disorders and diabetes. Although much work is left to be done in uncovering the underlying mechanisms of SCD, response of the sympathetic nervous system to a prolonged stressful stimulus and the release of excessive amounts of catecholamines and their subsequent oxidation has potential to explain the regularly observed etiologies and provide a unified mechanism for the occurrence of SCD. Current possible treatments for patients at risk for SCD range from the implantation of cardioverter defibrillators to pharmaceutical interventions including anti-arrhythmic drugs, antiplatelet ag.. Read More»
    DOI: 10.4172/2368-0512.1000074