Opinion
Modeling improvements for mitochondrial disease caused by mt-tRNA mutations: Patients' brain in a dish
Author(s): Samantha Brooks*
A diverse range of uncommon genetic abnormalities known as mitochondrial diseases can result from mutations in either the nuclear (nDNA) or mitochondrial DNA (mtDNA). Multiple maternally inherited genetic illnesses are linked to mtDNA mutations, with mitochondrial dysfunction as a key clinical trait. Although typically multisystemic, these disorders mostly affect the brain and skeletal muscles, two organs that demand a lot of energy. The discovery of induced pluripotent stem cells (iPSCs), in contrast to the challenge of acquiring neuronal and muscle cell models, has aided in the understanding of mitochondrial illnesses. A suitable cellular model is still difficult to come by, which makes it difficult to develop novel treatments for those who suffer from these disorders. In this review, we expand our understanding of the current therapeutic models for the two most well-studied mt-tRNA.. Read More»
DOI:
10.37532/ puljcgg.22.5 (1).1-2
