Opinion
hnRNP E1 controls the expression of the HPV16 oncogene and prevents cervical cancer
Author(s): Sander Gliboff*
Heterogeneous nuclear ribonucleoprotein E1, also known as hnRNP E1, is an essential RNA-Binding Protein (RBP) that is essential for the growth of tumors. The development of HPV-associated malignancy and the expression of the HPV gene are both influenced by the presence of several RNA/DNA binding sites and various RBPs on the Human papillomavirus 16 (HPV16). It is yet unknown how hnRNP E1 affects HPV16 oncogenes in the growth of cervical lesions. A community-based cohort was established in Shanxi Province, China, with a total of 816 participants who had cervical lesions of various grades. The relationship between the expression of hnRNP E1 mRNA and cervical lesions was examined using data from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases. We created cells that have hnRNP E1 up- and downregulated. Cell counting kit-8, analyses from flow cytometry, and c.. Read More»
DOI:
10.37532. puljcgg.22.5(2)1-2
