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Nephropathy is known to be an significant microvascular complication of diabetes mellitus that affects about one third of all diabetes patients. It usually induces early stage albuminuria with glomerular hyperfiltration and renal hypertrophy, frequently suggesting a weakening pathway that may lead to renal failure in the end stage. Histopathologically, glomerulosclerosis with thickening of the glomerular basement membrane, podocyte defects (terminally separated cells in the Bowman kidney capsule) and accumulation of extracellular matrix in the glomerular mesangial area is characterized by diabetic nephropathy. Proper treatment of hyperglycemia, hypertension and serum lipid levels in diabetic patients is important in preventing nephropathy from developing and progressing.

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Clinical Nephrology and Research received 35 citations as per Google Scholar report