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Sadia Idrees, Zeeshan Anjum, Naheed Bashir Awan, Syeda Ain-ul-Btool, Farhat Rafique Kiani, Qudir Javed, Mohsan Hanif,Fauzia Saeed and Ghazanfar Ali
Department of Biotechnology, University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan Department of Zoology, University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan
Posters & Accepted Abstracts: J Neurol Clin Neurosci
Statement of the Problem: Large scale epidemiological studies on inherited/congenital neurological diseases are rare in Pakistan and also in Azad Jammu and Kashmir. Therefore, we conducted a population based cross sectional epidemiological study on a stratified randomly selected samples from the four major districts of AJ &K to study the four major inherited/ congenital neurological disorders which includes; intellectual disability, microcephaly, neuromuscular dystrophy and Parkinson’s disease.
Methodology: Families with inherited/congenital neurological disorders were randomly recruited through door to door survey. Approval for this study was obtained by board of advanced studies from University of Azad Jammu and Kashmir.
Findings: Total 10,000 individuals were selected for interview among which 9711 (97.11%) took part in the study while 289(2.89%) refuse to take part in this study. Among responsive, the total number of affected individuals with different neurological disorders was 466 (4.80%) with an age range of 1-60 years. According to this data prevalence of neurological disorders in males was more 272 (5.67%) than the females 194(3.94%). The highest prevalence was recorded in age <18 years 253 (6.40%). Among the total positive cases intellectual disability was most frequent 337 (72.31%), followed by microcephaly 64 (13.7%), neuromuscular dystrophy 51(10.90%) and Parkinson 14 (3. 00%).
Conclusion & Significance: Present data suggests that inherited intellectual disability is the most frequent among all neurological disorders so further exploration, population base studies and genetic counseling is necessary.
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