The effect of vitamin D supplementation on breast density changes: A clinical trial study

Joint Event on 45^th World Congress on Nursing Care & 8^th European Breast Congress

December 11-13, 2017 | Rome, Italy

Sadaf Alipour, Azin Saberi, Leila Bayani, Nooshin Shirzad, Mahdi Sepidarkish and Ladan Hosseini

Vali-e-Asr Reproduction Health Research Center, TUMS, Iran Arash Women��?s Hospital, Tehran, Iran EMRI-TUMS, Iran Valiasr Hospital, TUMS, Iran Royan Institute for Reproductive Biomedicine - ACECR, Iran

ScientificTracks Abstracts: J Nurs Res Pract

Abstract :

Background: Previous evidence suggests that vitamin D reduces the incidence and mortality of breast cancer. The aim of this study was to determine the effect of supplementation with 50,000 IU/monthly vitamin D for one year on breast density in Iranian women. Methods: This double-blind, placebo-controlled, single center clinical trial was conducted among 500 women aged 40 years and older. Participants were allocated to two groups. Group 1 received vitamin D 50,000 IU in tablet form, monthly, for one year. Group 2 received vitamin E 400 IU in tablet form, for the same period of time. Participants had follow up clinic visits every six months and received an annual mammogram. Results: Final data were evaluated based on 216 and 194 women in the treatment and control groups. The mean decrease in mammographic density was -5.01% (95% CI, -9.9% to -0.01%) and -2.34%(95% CI, -6.84% to -2.15%) in the treatment and control groups, respectively. There was no significant association between vitamin D consumption and breast density after one year (OR=0.7, 95% CI, 0.46 to 1.06; P=0.1). Similar results were observed when multivariate model of logistic regression analysis was performed and vitamin D consumption was not significantly associated with breast density, independent of other variables (OR=1.07.95% CI, 0.58 to 1.96; P=0.8). Discussion: This study showed that monthly consumption of 50,000 IU of vitamin D supplementation for one year did not effect on breast density.

Biography :

Sadaf Alipour , MD , Cancer Surgeon, Breast Surgeon was an Associate professor in Surgery in Arash Women’s Hospital, Tehran University of Medical Sciences. She is interested in the  Field of Breast Cancer, Breast Surgery.