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Abderraouf Ayachi
University of Tebessa, Algeria
ScientificTracks Abstracts: Clin Pharmacol Toxicol Res
Lambda cyhalothrin is a synthetic pyrethroid insecticide, which is increasingly used in agriculture and home pest control. Our experimental study was carried out on 18 male WISTAR rats (Rattus rattus) divided into three groups: group A (06 rats) control, group B (06 rats) treated with LCT (05 mg / kg / day), group C (06 rats) treated with LCT (10 mg / kg / day) administered orally for 90 days The present work involves the evaluation of the potential toxicity of LCT on the kidneys of rats and the variation of some on oxidative stress parameters. The results obtained after the administration of LCT show that it has caused a generally prooxidizing effect, this is revealed by the reduction of the reduced glutathione level GSH and the enzymatic activity of the glutathione peroxidase GPx and catalase CAT in the kidneys and also by increasing the enzymatic activity of glutathione-Stransferase GST and the level of MDA in treated rats with different doses compared to controls. All of these results are signs of possible nephrotoxicity.
Abderraouf Ayachi has a BA and MA in Applied Toxicology from the Faculty of Exact Sciences and Nature and Life Sciences, University of Tebessa, Algeria as well as a Biologist in the Laboratory of the Mother and Child Hospital in Tebessa, Algeria. He has a great desire to develop his knowledge in the field of scientific research and gain more experience.
E-mail: raouf1794@gmail.com
