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Journal of Kidney Treatment and Diagnosis

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Adaptive nephrology

Author(s): Hanna Koch* and Paul Hohenlohe

Evolutionary medicine, a new field that broadens study boundaries, has evolved in the last 20 years. Progressive kidney disease follows nephron loss, hyperfiltration, and inadequate healing, a process known as "maladaptive." Evolutionary adaptation, in contrast to physiological (homeostatic) adaptation, is the result of reproductive success, which represents natural selection. Environmental mismatch or evolutionary trade-offs can lead to evolutionary reasons for physiologically maladaptive responses. A fragile, energy-hungry renal tubule and a hypoxic, hyperosmolar microenvironment were produced as a result of evolutionary adaption to a terrestrial environment. Natural selection promotes a successful energy investment strategy: through the reproductive years, energy is committed to maintaining nephron integrity, but after age 40, this decreases due to senescence.


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Google Scholar citation report
Citations : 14

Journal of Kidney Treatment and Diagnosis received 14 citations as per Google Scholar report

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