44 2033180199
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Journal of Pulmonology

Sign up for email alert when new content gets added: Sign up

Anti- Inflammatory Effect of Streptocholorin in Cellular and Mouse Models Through TRIF

Author(s): Francis Oliver*

Streptochlorin, a tiny chemical produced from a marine actinomycete, possesses anti-angiogenic, anti-tumor, and anti-allergic properties. The anti-inflammatory effects and underlying mechanisms, however, have yet to be discovered. The effect of streptochlorin on Lipopolysaccharide (LPS)-induced inflammatory reactions in vitro and in vivo was examined in this work. Streptochlorin inhibited the Toll/Interleukin-1 receptor (TIR)-domain-containing adaptor, which reduced the generation of proinflammatory mediators such as nitric oxide, cyclooxygenase-2, pro-interleukin (IL)-1, and IL-6 in LPS-stimulated RAW264.7 cells. TRIF-dependent signalling mechanism that induces interferon In the LPS-induced Acute Lung Injury (ALI) animal model, streptochlorin inhibited the infiltration of immune cells such as neutrophils into the lung and the generation of proinflammatory cytokines such as IL-6 and TNF- in Broncho-Alveolar Lavage Fluid (BALF). Streptochlorin exhibits powerful anti-inflammatory effects by modulating TRIF-dependent signalling pathways, suggesting that it could be a useful therapeutic method for a variety of inflammatory illnesses.


PDF
 
Google Scholar citation report
Citations : 9

Journal of Pulmonology received 9 citations as per Google Scholar report

pulsus-health-tech
Top