44 2033180199
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Journal of Biomolecules and Biochemistry

Sign up for email alert when new content gets added: Sign up

Evaluation of placental prostate specific antigen, estradiol and interleukin-6 and their significance in preeclampsia

Author(s): Nadia YS Morcos, Mahmoud M. Said*, May MM Tadros and Fady M Benjamine

OBJECTIVES: The aim of the current study was to evaluate the level of some placental parameters and their probable correlation with increased risk of preeclampsia. SUBJECTS AND METHODS: The study included a total of fifty women, including twenty five pregnant women with preeclampsia and twenty five normotensive pregnant females. The placental biomarkers studied at delivery included prostate specific antigen (PSA), 17-β estradiol (E2), interleukin-6 (IL-6), lipid peroxidation (MDA), glutathione peroxidase (GPx) and trace elements (zinc, copper and calcium). RESULTS: A significant difference was recorded in placental PSA (p<0.002), E2 (p<0.012) and IL-6 (p<0.05) levels in preeclamptic women, compared to normotensive pregnant ones. In addition, a significant negative correlation was found between placental PSA with IL-6 and E2. CONCLUSIONS: Our study demonstrated increased placental PSA and reduced E2 and IL-6 levels as PE-associated biomarkers. Furthermore, the recorded correlation between placental PSA and E2 may represent a new understanding in PE pathogenesis.


Full-Text | PDF
 
pulsus-health-tech
Top