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Clinical Pharmacology and Toxicology Research

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Haloperidol in lieu of conventional therapy in the treatment of diabetic related gastroparesis in the emergency department

Author(s): William Heuser , Shayna Carp, Justin Fuehrer, Michael Harrington, Michelle Komlo and Seungjun Ahn

Diabetic associated gastroparesis (GP), manifested by intractable vomiting, nausea, and abdominal pain, and is a common presentation to the emergency department (ED). Conventional treatment is focused on symptomatic management and has historically focused on the use of prokinetic agents, and antiemetics, with or without an opioid agent for intractable pain; however, no algorithm currently exists. Given its novel mechanism of action as a dopamine-2 (D2) receptor antagonist, haloperidol may be an effective alternative agent, due to its analgesic and antiemetic properties. This study seeks to determine if using haloperidol in lieu of conventional agents reduces overall ED length of stay and reduces hospital admissions.


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