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In the treatment of mental illness, addictions, and end-of-life distress, psychedelic-assisted therapy is displaying unparalleled rates of success. This psychedelic renaissance marks a watershed moment in the treatment of complex human illnesses, with consequences for nursing knowledge, advocacy, and practice around the world. The purpose of this article is to examine the present level of knowledge in the field of psychedelic-assisted therapy, as well as the implications for nurses in practice. With a focus on mental health, addictions, and palliative care indications, a scoping review of the literature was conducted. All relevant main study results, as well as commentaries, syntheses, and reviews over the last 20 years, were included. We then looked at what is known about the nurse's function in this profession in the past and current. The nurse's function in psychedelic-assisted therapy and research has been essentially inconspicuous up until now, and as a result, it has remained under-explored and unclear. However, the profession is well positioned to contribute to the field's future success. Nurses may lead the development of psychedelic-assisted therapeutic practice, ethics, research, advocacy, policy, and education as advocates for safe, ethical, and transdisciplinary practice. In these areas, this article offers advice and assistance for forward-thinking nursing leadership.
