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Sickle Cell Disease (SCD) affects all the domains of quality of life in the affected children, including the physical, psychosocial, and cognitive and morbidity domains. This effect will be augmented in the presence of an impaired pulmonary function test. There are no studies that correlated the degree of impaired pulmonary function in children with SCD with the degree of impairment of their quality of life. Besides, it is very challenging to segregate the effect of SCD on the child’s quality of life from impaired pulmonary function. Hence more studies are needed.