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The high use of methamphetamine among adolescents of millennial age has an impact on the occurrence of dependence with chronic use and has an impact on the brain that has an impact on cognitive impairment, so researchers want to look at risk factors that affect cognitive function in methamphetamine use. This cross-sectional study took place at the Insyaf rehabilitation center in North Sumatera Province. Conducted with a period of March 2019 to November 2019 with a total sample of 101 people collected using the consecutive sampling method, Willing to participate in the study, Male. 15-40 years old, cooperative and understands Indonesian, history of methamphetamine use 1 year, meets criteria for methamphetamine use disorder, has abstinence 1 month, total WHO ASSIST questionnaire for methamphetamine 4. This study showed that as many as 57 people with chronic methamphetamine users had a cognitive decline and the factors affecting cognitive function in methamphetamine users were using ecstasy. They are at risk for impaired cognitive function with a risk value of 2,560. Individuals who use chronic methamphetamine together with ecstasy will be at risk of experiencing cognitive function impairment even though they have been abstinent for more than one month.
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