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Substance use related disorders are major concerns for Bangladesh due to the increasing burden on family, society and nation. Various family and social factors contribute to the development of these disorders. However, the relevant factors were yet to be explored in the Bangladesh from multiple sites study. This study aimed to attempt find out the Social and Family determinants of substance abuse. It was a cross sectional study where one hundred and one substance users were interviewed from two tertiary level hospitals in the Dhaka. Peer pressure and parental disputes were significant contributing factors for substance dependence and discussion about the adverse effect of the substance abuse in family had protective role. The study findings will help in planning the preventive program substance dependence.