Unusual Presentation of a Uterine Leiomyosarcoma with Predominant Metastasis to the Liver: A Case Report with Gross and Histological Validation

Uterine Leiomyosarcoma (uLMS) are malignant mesenchymal tumors known to metastasize preferentially to the lungs. The present study concerns a female human body donor of postmenopausal age with known diagnosis of uLMS. Upon dissection and gross examination, an enlarged uterus and tumor-ridden liver were observed, however the lungs appeared typical except for a single palpable nodule on the superior lobe of the left lung. Immunohistochemical analysis of the liver tumors confirmed their myogenic origin and thus suggested uLMS distant metastasis, but the analyses of the lung nodule showed typical tissue architecture with no presence of myosin or actin. Illustrating gross and histological analyses of this unusual case with the relevant clinical information may assist biomedical research scientists, inform medical educators, and help physicians better understand uLMS with this metastatic pattern.